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July 1998 Newsletter
Boosting Exercise Performance
Recently pyruvate, a stabilized form of pyruvic acid, and its sister
compound, dihydroxyacetone, have become popular dietary supplements
in sports nutrition. Together they are referred to as DHAP. Use of these
nutrients is backed by scientific evidence showing that they augment
muscle glycogen, fat loss and exercise endurance.
DHAP supplements appear to improve athletic endurance by enhancing
"glucose extraction" or the amount of glucose that muscle cells can
take from the circulating blood. When exercised, muscle cells can then
burn the glucose for energy; at rest, they can store it as glycogen.
David Costill, Ph.D., director of the Human Performance Laboratory
at Ball State University in Muncie, IN, assigned trained runners to
three dietary regimens that varied in carbohydrate content. Group one
consumed 25% of their total 3000 calories as carbohydrate; group two
50%; and group three 70%. To measure glycogen content, researchers took
muscle biopsies immediately after exercise, and again 24 hours later.
The results demonstrated that during the 24-hour period muscle-glycogen
synthesis increased in proportion to the amount of carbohydrate consumed.
In the past, experts advised that athletes eat their carbohydrates
in complex form such as brown rice, whole-grain breads, and pastas.
Then glucose polymer drinks were used to replace glycogen stores without
the added bulk of whole grains in the intestinal tract. More recent
research has shown that dihydroxyacetone and pyruvate increase muscle-glycogen
stores more effectively than glucose polymers.
Two double-blind studies conducted at the University of Pittsburgh
Medical Center in Pittsburg, PA, showed that seven days of DHAP supplementation
to athletes on both normal and high-carbohydrate diets significantly
improved exercise performance compared to a carbohydrate placebo.
A third double-blind study showed that while cycling at the same workloads,
subjects taking DHAP reported a more than 20% decrease in perceived
level of exertion.
Researchers have yet to determine the optimal pyruvate allowance. Total
daily intake ranges from 100 mg to 1-2 grams. Foods high in pyruvate
include certain fruits, vegetables, and cheeses. A red apple packs 450
mg.
No major side effects have been associated with pyruvate or DHAP.
Since it has many metabolic effects, pyruvate supplementation is not
recommended for pregnant women or children.
Reference: Stanko, R.T., Robertson, R.J., Spina, R.J., et al. "Enhancement
of arm exercise endurance capacity with dihydroxyacetone and pyruvate."
J Appl Physiol, 68: 119-24, 1990.

Probiotics Provide Balance
Some 60 to 70 million Americans suffer from digestive diseases of one
kind or another and spend $107 billion on drugs and antacids annually.
Digestion is the process that powers the bodyconverting food into
a usable form of energy that is used in turn to create health and vitality.
Interference with this crucial process can lead to chronic fatigue, premature
aging, arthritis, poor skin and hair, toxicity, allergies, and cancer.
One way to ensure proper digestion and health is to nurture the body's
naturally occurring microorganisms. Billions of bacteria live in the gastrointestinal
tract. Some are helpful, while others can cause problems. The body depends
on the colon's beneficial bacteria to manufacture B vitamins including
biotin, niacin, folic acid, and pyridoxine. In addition, these microorganisms
produce antibacterial substances that kill disease-causing agents such
as salmonella and some types of E. coli.
Two of the more predominant types of beneficial bacteria in a healthy
human being are acidophilus bacteria (found in the small and, to a lesser
extent, large intestines) and bifidobacterium (found primarily in the
large intestine).
High-meat, high-fat diets alter colonic pH and kill helpful bacteria,
as do alcohol, stress, and drugs such as birth control pills. Antibiotics
are particularly effective at killing all kinds of bacteria, both good
and badsometimes leading to candida overgrowth and yeast infections.
Probiotics, dietary supplements made of beneficial microorganisms, can
reintroduce beneficial bacteria.
Because they convert cholesterol into a less absorbable form, probiotics
may hamper the intestinal tract's cholesterol absorptionthereby
decreasing serum cholesterol levels. There is also some indication that
probiotics can reduce the generation of toxic and cancer-causing compounds
produced in the intestinal tract. A study published in the Annals of Internal
Medicine suggests that L. acidophilus may reduce the recurrence of vaginal
infections caused by candida.
Probiotic supplements offer a safe, natural, and effective way of maintaining
gastrointestinal function. Considering the importance of digestion to
overall health, when digestive problems occur, it is an investment worth
making.
Reference: Kochar, N., Mehta, A., et al. "In vitro effect of lactobacilli
on intestinal anaerobic flora and intestinal gas." Microecol Ther, 19:
119-20, 1989.

Ginseng May Help Diabetics
Writing in Diabetes Care, E.A. Sotaniemi, et al., said that ginseng may
be a useful therapeutic tool for the management of non-insulin-dependent
(Type II) diabetes.
In the study, 36 volunteers with recently diagnosed Type II diabetes
mellitus were given 100 to 200 mg per day of ginseng or a placebo for
eight weeks.
The researchers said that the supplement was associated with elevated
mood, improved psychophysical performance, lowered fasting blood glucose
levels, and lower body weight when compared with typical levels of these
parameters in diabetics generally. No side effects were noted.
The researchers added that the 200 mg dose of ginseng enhanced physical
activity and improved other variables associated with the disease.
Reference: Sotaniemi, E. A., et al., Diabetes Care; 18:1373-5, October,
1995.

Revitalize Your Liver
The liver is our largest organ, with as many as 500 vital functions.
Nearly all products absorbed during digestion initially pass through the
liver where it removes or modifies toxic substances before passing remains
into general circulation.
The liver stores blood and fat-soluble vitamins. It aids food digestion
and metabolism by making cholesterol and bile. After a carbohydrate-rich
meal, the liver will convert some of the excess glucose into glycogen.
During fasts, the liver releases glucose into the blood by breaking down
its glycogen stores.
Optimum health depends on a sound liver. In most illnesses, health practitioners
would do well to assess the status of a patient's liver. If liver function
can be improved, the entire system will usually benefit.
Normally, the liver needs protein to repair itself. The sulfur-containing
amino acids methionine, cysteine, and taurine are particularly important.
Antioxidants also facilitate liver healing. Supplementing the diet with
vitamins C and E and the minerals zinc and selenium can help protect the
liver from free radical damage. In addition, the B complex vitamins, particularly
choline, may support regeneration.
Phosphatidylcholine, more popularly known as lecithin, not only maintains
the integrity of liver cells but also may help regenerate damaged tissue
and normalize bile function. Studies have found lecithin to improve health
in alcoholic liver disease and viral hepatitis and to protect the liver
against a variety of toxins.
Silymarin (Silybum marianum), a constituent of milk thistle, is a powerful
antioxidant and lipotropic agent and has been shown to stimulate the growth
of new liver cells.
Dandelion (Taraxacum officinale), a nutrient-rich herb, has a long folk
history as a liver tonic. The German Commission E reports that the root
and leaves stimulate bile production, thereby diminishing liver congestion.
Reference: Wagner, H. "Plant constituents with anti-hepatotoxic activity."
Beal, J., & Reinhard, E., eds. Natural Products as Medicinal Agents:
545-8, 1981.

Repelling Insects Naturally
If you don't like sharing the great outdoors with mosquitoes and other
biting bugs you could do something natural to protect yourself from those
pesky blood suckers.
Many of the commercial insect repellents available contain a substance
called DEET (N,N-diethyl-m-toluamide) which, while an effective insect
repellent, can be toxic if used excessively, particularly on children.
Dr. Michael Watson, a board-certified toxicologist with the Environmental
Protection Agency, said that "while reasonable application of DEET-containing
products on adults is not generally a problem, extra caution should be
exercised if such products are used on children."
He explained, "The liver tries to metabolize DEET and get it out of the
body, but the metabolism isn't very rapid and after significant, repeated
exposure, the DEET may remain lodged and stored in the skin. In small
children, there's lots of skin relative to body size, so if DEET is put
on them every day, there's a lot of possible loading going on."
Fortunately, there are alternatives to DEET with a variety of herbs that
act as natural repellents. Because insects have an amazing sense of smell,
odor is used as the basic element in most repellents. Four herbs which
have been shown to act as natural insect repellents when applied to the
skin are:
Eucalyptus: The leaves and oil from the eucalyptus tree are an extremely
potent antiseptic, and are also useful for repelling fleas.
Pennyroyal: This herb has a long history of use as an insect repellent.
It is a common ingredient in many herbal repellents.
Citronella: Distilled from Cymbopogon (Andropogon) nardus, citronella
may be the most well-known natural insect repellent. Not only is it a
common ingredient in natural topical repellents, but many light citronella
candles to keep insects away.
Geranium Oil: According to work cited by The American Botanical Council,
geranium oil has been proven to be an effective insect repellent.
Reference: Keville, Kathi. Herbs for Health and Healing, 1996.

Hope For Fibromyalgia
Three to six million people suffering from fibromyalgia are women 25-45
years old. They report the primary symptoms of aches and pains in their
muscles, tendons, and ligaments, fatigue, swelling, muscle spasms, stiffness,
headache, and difficulty getting a "good" night's sleep. Fibromyalgia
may be hereditary.
Since the symptoms are vague, misdiagnosis is common. Although fibromyalgia
generally emerges between the ages of 29 and 37, most people are not correctly
diagnosed until the ages of 34 to 53with the intervening years often
spent being treated for one of the misdiagnosed conditions.
Treatment for fibromyalgia, until a cure is found, focuses on easing
the symptoms of this disease.
Several studies involving patients with fibromyalgia suggest that a combination
supplement providing magnesium and malic acid can relieve muscle pain.
The individuals in these studies, after taking 300-600 mg of magnesium
and 1200-2400 mg of malic acid each day for eight weeks, reported significant
pain relief. When the magnesium/malic acid supplements were secretly switched
with placebos, the pain returned, indicating that the supplement was helping
control the pain.
Vitamin B1 may also be helpful in easing fibromyalgia, since some studies
have found fibromyalgia patients to have low thiamin status. Vitamin E
supplements are recommended by some clinicians as part of a dietary supplement
plan for fibromyalgia.
Exercise is among the most important recommendations for people with
fibromyalgia. Start out with low-impact aerobic exercise, such as bicycling,
or walking, and build up to 20-minute sessions three to four times per
week.
Reference: Abraham, G., and Flechas, J. "Management of fibromyalgia:
rational for the use of magnesium and malic acid", J Nutr Med 3:49-59,
1992.
Older women taking vitamin C supplements for 10 years or longer were
found to have a 77-83% lower risk of developing various kinds of cataracts,
compared to women who did not take such supplements. Women taking vitamin
C supplements sporadically or for less than 10 years did not benefit from
the vision protection of long-term vitamin C supplementation.
Reference: American Journal of Clinical Nutrition 66:911-6, 1997.
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