Patient Education  

Ginseng, Asian
Plant Description
What's It Made Of?
Available Forms
How to Take It
Precautions
Possible Interactions
Supporting Research


Ginseng is a light tan, gnarled root, regarded by people in Asian countries to be the king of all herbs. Sometimes the main part of the root looks like a human body, with stringy shoots that look like arms and legs. Herbalists hundreds of years ago took this appearance to mean that ginseng could cure all human ills, and it has been used as a cure-all by many different cultures. The Chinese, however, view ginseng not only as a cure-all, but also as a plant that brings longevity, strength, and wisdom to its users.

American and Asian ginsengs are useful in the treatment of diabetes, fatigue, for alleviating stress, and during convalescence, and Siberian ginseng for stress, fatigue, atherosclerosis, and impaired kidney function. Confusion regarding which ginseng (American, Asian, or Siberian) to use for stress, fatigue, and convalescence stems from the suggestion that active components in one type are superior to those in another type. Such superiority has not been demonstrated. Early Russian studies indicated that Siberian ginseng's positive effects exceed those of Asian ginseng's. These results are supported by empirical reports, but have been challenged by investigators who question the validity of the studies and the quality of the Siberian ginseng preparation. At this time, all three ginsengs are regarded as adaptogens, all three have the same side effects, and despite qualitative differences, each is used for similar treatments. Cost, standardization, and the reputation of the manufacturer may be the deciding points in determining which product to use.

Ginseng increases stamina, strength, and well-being. These actions make it sound like a stimulant, such as coffee. But stimulant drugs often compromise the actions of important parts of the body, and irritability, heart palpitations, addiction, and anxiety are some of the side effects that may result. Ginseng, on the other hand, acts without any of these negative effects, and it has been used safely for at least 2,000 years.

Your doctor may recommend ginseng if you have just had an illness. If you are elderly, ginseng may shorten the time that it takes you to bounce back from illness or surgery. It may also help you to focus your thoughts.

If you are someone who tends to get a lot of colds or sore throats you may find that taking ginseng reduces the frequency of these conditions. Ginseng may help if you have difficulty concentrating. Athletes take ginseng to increase both endurance and strength. Ginseng may also help reduce the discomforts of menopause.

Ginseng acts as an adaptogen, which helps the body fight against the effects of just about any kind of stress, be it viral, bacterial, emotional, intellectual, or physical. The effects of stress may be as simple as headaches or colds, but they can also be more serious, such as accelerated aging, memory loss, heart disease, cancer, and arthritis.


Plant Description

The ginseng plant has leaves that grow in a circle around a straight stem. Yellowish-green umbrella-shaped flowers grow in the center and produce red berries. Wrinkles around the neck of the root tell how old the plant is. This is important because ginseng is not ready for use until it has grown for four to six years.


What's It Made Of?

Ginseng products are made from the ginseng root, and the long, thin offshoots, called root hairs. The main chemical ingredients in Asian ginseng are the ginsenosides (Rg1 as marker); glycans (panaxans); polysaccharide fraction DPG-3-2; peptides; maltol; and volatile oil.


Available Forms

White ginseng (dried, peeled) or red ginseng (unpeeled root, steamed before drying) is available in water, water-and-alcohol, or alcohol liquid extracts, and in powders or capsules.


How to Take It

When taking ginseng, use only standardized products. Standardization is the only way we have of assuring quality in herbal products. Choose white or red ginseng, standardized to 1.5 percent ginsenosides, designated as Rg1.

The recommended dose is 1 to 2 g fresh root, 0.6 to 2 g dried root, or 200 to 600 mg liquid extract daily.

If you are healthy and are using ginseng to increase your physical or mental performance, to prevent illness, or to improve resistance to stress, you should take ginseng at the recommended dosage in cycles. For example, take 1 to 2 g fresh root, 0.6 to 2 g dried root, or 200 to 600 mg liquid extract daily for 15 to 20 days, followed by two weeks without taking ginseng.

For help recovering from an illness, the elderly should either take 0.5 g twice a day for three months and then stop or take 0.5 g twice a day for a month, followed by a two-month break. Repeat if desired.


Precautions

The American Herbal Products Association (AHPA) rates ginseng as a class 2d herb, which indicates that specific restrictions apply. In this case, hypertension (high blood pressure) is the specific restriction, so people with hypertension should not take ginseng products. Likewise, you should not use ginseng with caffeine or other medications that stimulate the central nervous system because this herb may increase the effects of these substances, possibly making you feel nervous or causing sweating, insomnia, or irregular heartbeat.

People with heart disease, diabetes, and low blood pressure should use caution when taking ginseng. Do not take ginseng during any acute illness. Do not use ginseng if you are pregnant because its safety during pregnancy has not been determined.


Possible Interactions

One study reported that ginseng may increase the effects of digoxin, a medication used to treat heart conditions. You should consult with your doctor before using ginseng with digoxin in order to assure that it is appropriate for you to combine the two.

There have been reports of a possible interaction between ginseng and the antidepressant medication, phenelzine, resulting in symptoms ranging from manic-like episodes to headache and tremulousness. Therefore, you should not use ginseng with phenelzine.

There have been reports that Asian ginseng may possibly decrease the effectiveness of the blood-thinning medication, warfarin. If you are currently on warfarin therapy, you should refrain from taking Asian ginseng.

Ginseng may block the effects of analgesic medications such as morphine. You should not use ginseng with morphine except on the advice of your doctor.


Supporting Research

Aphale AA, Chhibba AD, Kumbhakarna NR, et al. Subacute toxicity study of the combination of ginseng (Panax ginseng) and ashwagandha (Withania somnifera) in rats: a safety assessment. Indian J Physiol Pharmacol. 1998;42(2):299–302.

Bahrke M, Morgan P. Evaluation of the ergogenic properties of ginseng. Sports Medicine. 1994;18:229–248.

Blumenthal M, ed. The Complete German Commission E Monographs. Boston, Mass: Integrative Medicine Communications; 1998.

Blumenthal M, Riggins C. Popular Herbs in the U.S. Market: Therapeutic Monographs. Austin, Tex: The American Botanical Council; 1997.

Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, Ore: Eclectic Medical; 1998:77.

Cheng TO. Ginseng-warfarin interaction. ACC Curr J Rev. 2000;9(1):84.

Choi HK, Seong DH, Rha KH. Clinical Efficacy of Korean red ginseng for erectile dysfunction. Int J Impotence Res. 1995;7:181–186.

D'Angelo L, et al. A double-blind, placebo-controlled clinical study on the effect of a standardized ginseng extract on psychomotor performance in healthy volunteer. J Ethnopharmacol. 1986;16:15–22.

Dega H, Laporte JL, Frances C, Herson S, Chosidow O. Ginseng as a cause for Stevens-Johnson Syndrome? Lancet. 1996;347:1344.

De Smet PAGM, Keller K, Hansel R, Chandler RF, eds. Adverse Effects of Herbal Drugs. New York, NY: Springer-Verlag; 1992:1.

Ding DZ, Shen TK, Cui YZ, et al. The effects of red ginseng on the congestive heart failure and its mechanism [in Chinese]. Chung Kuo Chung His I Chieh Ho Tsa Chih. 1995;15(6):325-327.

Dorling E. Do ginsenosides influence the performance? Results of a double-blind study. Notabene medici. 1980;10:241–246.

Foster S. Asian Ginseng. Austin, Tex: The American Botanical Council; 1996.

Grandhi A, Mujumdar AM, Patwardhan B. A comparative pharmacologic investigation of ashwagandha and ginseng. J Ethnopharmacol. 1994;44:131–135.

Gross D, Krieger D, Efrat R, Dayan M. Ginseng extract G115 for the treatment of chronic respiratory diseases. Schweizerische Zeitschrift fur Ganzheits Medizin. 1995;1(95):29–33.

Hardman JG, Limbird LE, Molinoff PB, et al. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: Pergamon Press; 1996.

Huang KC. The Pharmacology of Chinese Herbs. Boca Raton, Fla: CRC Press; 1993.

Janetsky K, Morreale AP. Probable interaction between warfarin and ginseng. Am J Health-System Pharm. 1997;54:692–693.

Jones BD, Runikis AM. Interactions of ginseng with phenelzine. J Clin Psychopharmacol. 1987;7:201–202.

Kim HS, Jang CG, Oh KW, et al. Effects of ginseng total saponin on morphine-induced hyperactivity and conditioned place preference in mice. J Ethnopharmacol. 1998;60(1):33–42.

Koo MW. Effects of ginseng on ethanol-induced sedation in mice. Life Sci. 1999;64(2):153–160.

Kowalchik C, Hylton W, eds. Rodale's Illustrated Encyclopedia of Herbs. Emmaus, Pa: Rodale Press; 1998.

Kuo SC, Teng CM , Lee JC, et al. Antiplatelet components in Panax ginseng. Planta Med. 1990;56:164–167.

McGuffin M, Hobbs C, Upton R, Goldberg A. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, Fla: CRC Press; 1996.

Miller LG. Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med. 1998;158(20):2200–2211.

Murray M. The Healing Power of Herbs: the Enlightened Person's Guide to the Wonders of Medicinal Plants. Rocklin, Calif: Prima Publishing; 1995.

Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health Care Professionals. London, England: The Pharmaceutical Press; 1996.

Nitta H, Matsumoto K, Shimizu M, et al. Panax ginseng extract improves the scopolamine-induced disruption of 8-arm radial maze performance in rats. Biol Pharm Bull. 1995;18(10):1439–1442.

Oh KW, Kim HS, Wagner GC. Ginseng total saponin inhibits the dopaminergic depletions induced by methamphetamine. Planta Med. 1998;63(1):80–81.

Petkov VD, Konstantinova E, Petkov VV, et al. Modulation of the effects on learning and memory of noötropic drugs and central stimulants when applied together. Acta Physiol Pharmacol Bulg. 1991;17(4):17–26.

Quiroga HA, Imbriano AE. The effect of Panax ginseng extract on cerebrovascular deficits. Orientacion Medica. 1979;1208:86–87.

Quiroga HA. Comparative double-blind study of the effect of Ginsana Gii5 and Hydergin on cerebrovascular deficits. Orientacion Medica. 1982;1281:201–202.

Schultz V, Hansel R, Tyler V. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. New York, NY: Springer; 1998.

Shader RI, Greenblatt DJ. Phenelzine and the dream machine. Ramblings and reflections. J Clin Psychother. 1985;5:65.

Siegel RK. Ginseng abuse syndrome. JAMA. 1979;241:1614–1615.

Sotaniemi EA, Haapakoski E, Rautio A. Ginseng therapy in non–insulin-dependent diabetic patients. Diabetes Care. 1995;18(10):1373–1375.

Sun XB, Matsumoto T, Yamada H. Purification of immune complexes clearance enhancing polysaccharide from the leaves of Panax ginseng, and its biological activities. Phytomedicine. 1994;1:225–231.

Tachikawa E, Kudo K, Harada K, et al. Effects of ginseng saponins on responses induced by various receptor stimuli. Eur J Pharmacol. 1999;369(1):23–32.

Takahashi M, Tokuyama S. Pharmacological and physiological effects of ginseng on actions induced by opioids and psychostimulants. Meth Find Exp Clin Pharmacol. 1998;20(1):77-84.

Tang W, Eisenbrand G. Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine. New York, NY: Springer; 1992.

You JS, Hau DM, Chen KT, Huang HF. Combined effects of ginseng and radiotherapy on experimental liver cancer. Phytotherapy Research. 1995;9:331–335.

Zhu M, Chan KW, Ng LS, et al. Possible influences of ginseng on the pharmacokinetics and pharmacodynamics of warfarin in rats. J Pharm Pharmacol. 1999;51(2):175–180.


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The publisher does not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. No claims or endorsements are made for any drugs or compounds currently marketed or in investigative use. This material is not intended as a guide to self-medication. The reader is advised to discuss the information provided here with a doctor, pharmacist, nurse, or other authorized healthcare practitioner and to check product information (including package inserts) regarding dosage, precautions, warnings, interactions, and contraindications before administering any drug, herb, or supplement discussed herein.
 
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